Unlike the original Age of Mythology for the PC, Age of Empires: Mythologies is turn-based as opposed to real-time strategy, where in the vein of Advance Wars and the previous Age of Empires: The Age of Kings each player is given a turn where their units can make single actions within that turn such as moving to an opposing unit and attacking or capturing or constructing buildings. Every time two rival players' units attack one another, a brief animation of a group of each unit engaging in combat is played on the top screen, along with the resulting damage to their hit points. In standard games, players collect three resources; food, gold and favor to construct buildings and eventually train units for combat. To gain further units, technologies and buildings, players advance "Ages", starting in the "Archaic Age", a feature prominently used in the original Ensemble Studios Age of Empires series.
Like the original Age of Mythology, there are three civilizations available, Greek, Egyptian and Norse, each with their own unique units, buildings, powers and method of obtaining favor. Each has three “major” Gods to choose from before each game, these being Zeus, Hades and Poseidon for the Greeks; Ra, Isis and Set for the Egyptians and Odin, Thor and Loki for the Norse. Additionally, each has “minor” Gods to select from every time the player advances an age, with all deities granting the player unique technologies, perks, myth units and God powers that are used to damage or benefit players. There are three types of base unit, human, Hero and Myth, the latter two being a mythical figure or creature from the civilization’s mythology and legends, with a rock-paper-scissor model that governs which units are best suited against others - for example, humans being good against heroes but weak against myth units. Every unit also has a sub-category such as heavy infantry or archers, again with each being better suited against certain others. Human units could be hoplites or chariot archers, hero units can be Odysseus to Ramesses, and myth units could be a cyclops to a giant.