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Mass Effect & Mass Effect 2
Biotics possess extraordinary abilities, but they must live with minor inconveniences. The most obvious issue is getting adequate nutrition. Creating biotic mass effects takes such a toll on metabolism that active biotics develop ravenous appetites. The standard Alliance combat ration for a soldier is 3000 calories per day; biotics are given 4500, as well as a canteen of potent energy drink for quick refreshment after hard combat.
Another issue is electrical charge. Electricity accumulated in starship drive cores must be discharged, and so must the electricity in a biotic user. Biotics are prone to small static discharges when they touch metal.
Unfortunately, human biotics also face suspicion and persecution, beginning with the popular misconception they can read and control minds. Biotics symbolize the dehumanization of mankind to people philosophically or religiously opposed to gene modification and cybernetics. Militaries are the only organizations that always welcome biotics, offering them huge recruitment incentives.