College Football USA '97 was the fourth installment of the series. The game featured University of Nebraska quarterback Tommie Frazier on the cover.

The game added a new "create player" feature (up to 28 players) and custom schedules, new animations and all 111 Division I-A teams. Players could also compete in a customized Tournament with support for up to 16 players in a single-elimination or round robin format.

Players were also able to adjust penalties, set weather type, enter user records, perform substitutions, set audibles, toggle injuries, and change game length as well as difficulty level. Authentic playbooks (with plays like the Wishbone), a USA Today/CNN Coaches Poll, and the Sears National Championship Trophy were also available.