Crash: Mind over Mutant is an action/adventure video game published by Activision and developed by Radical Entertainment for the PlayStation 2, by Virtuous for the PlayStation Portable, and also developed for both the Wii and Xbox 360. The Nintendo DS version of the game was developed by TOSE. It was released in North America on October 7, 2008, and was released in Europe and Australia on October 31 and October 29 of that year, respectively. After Crash of the Titans, this is the second game in the series not to have a Japanese release.


Crash: Mind over Mutant is open world in which the player controls Crash Bandicoot, whose main objective is to explore his home, Wumpa Island, and surrounding environments to uncover the mystery behind the "NV", a personal digital assistant created by the main antagonist. Crash: Mind over Mutant is a mission-based game as opposed to Crash of the Titans' level-based structure, with goals being given by non-playable characters. Characters with exclamation points (!) over their heads, when talked to, give out important information that is needed to continue the story. Placed around Wumpa Island are special items that empower Crash in different ways. Crash can perform powerful attacks. He can also block, dodge, or break an enemy's block. When he defeats enemies or destroys objects, a magical substance known as Mojo is released, when collected, allows Crash's abilities to be upgraded.