The plot of D. D. Crew is themed after numerous North American action movies popular during the time. A man name F. F. got a phone call from a bombing terrorist, and heard him say that a bomb is in an amusement park, while F. F. rushes toward it with three partners: Buster, King and Gung Ho.
D. D. Crew is similar to Capcom's Final Fight, which is an archetypal side scrolling beat-em-up game. Up to four player characters move from left to right through each level (most of which are split into 3 or more scenes), fighting with the enemy characters who appear, until they reach a confrontation with a stronger boss character at the end of the level. Once that boss is beaten, the players automatically move on to the next stage. Enemies appear from both sides of the screen and from out of doorways or entrances set into the background, and the player(s) must defeat all of them to progress. If the players try to simply travel through the levels without fighting, the screen will stop scrolling until all current enemies have been defeated, before allowing the players to continue progress. Enemies may move outside the confines of the screen, but players may not. Players will pick up a few weapons along the way, like knifes and grenades, as well as other items like some lives and "MAX" health points. Players also can pick up and toss enemies either toward the ground or against other enemies. Unlike Final Fight, the graphics are very detailed instead of "cartoony". One unique feature is a counter that tells how many enemies a player knocked out. Another unique feature is that players also can perform dash attacks by pressing the joystick toward the left or right sides twice, while pressing the attack button during dashing.