Destroy All Humans! is a third-person action game that puts you in the position of a Furon in the America of the 1950s. It follows sandbox style gameplay similar to that of Grand Theft Auto III. It is known for it's light-hearted atmosphere and well crafted humor involving communism. There are many homages to old sci-fi movies, including some unlockable clips from them.
The game begins with an alien spacecraft being shot down accidentally by a nuke. The American army takes it hostage, and the opening scene ends. Then, it is revealed that the alien was a Furon clone, and his brother clone, Cryptosporidium-136 (or just Crypto) is sent to Earth to rescue him. After a few missions, his boss Orthopox-13 tells him that Furon cloning is degrading, and Crypto needs to extract dormant Furon DNA from humans. The Majestic, however, try to destroy him because they are trying to take control of America. Soon, Crypto discovers that his brother is dead, and vows revenge. However, Majestic then gains psychokinetic powers by unlocking the dormant Furon DNA in their brains. Crypto goes through several missions, shatters the army, and then goes to face the Majestic leader, Sillhouette. He faces the Robo-Prez, a 100-Foot Majestic Robot with the brain of the dead president Hoffman. Finally, he moves on to defeat Majestic's leader, pose as the President, and finally puts DNA extracting pods all across America, tricking citizens into thinking it is a medical checkup center.
Cryptosporidium-136 - A Furon Clone.
The predecessor of Crypto-137 (the player)
Orthopox-13 - Crypto's commander. He is the mastermind behind the Earth invasion. He lost his limbs in the Martian War. He now resides in a cerebro-chair, which he uses to move around and to support his very large cranium. He is not the Emperor of the Furons.