Duke Nukem 3D: Plutonium Pack (also known as Duke Nukem 3D: Plutonium PAK) was an expansion for Duke Nukem 3D.

The expansion pack contained a new eleven-level fourth episode, The Birth, as well as a new weapon, the Microwave Expander, two new enemies, the Protector Drone and the Pig Cop Tank, a final new boss, the Alien Queen, new graphics, new music, new voice-overs, and new sound effects

The Plutonium PAK includes several improvements to the scripting language, such as allowing new enemies and items to be created without having to overwrite the existing ones. Another new feature in the Plutonium PAK are the computer-controlled bots that allow fake multi-player games to be played ("fake" because there are no other human players). The bots are capable of putting up a decent fight, and can be useful for testing a user-made map to see how well it will play in multi-player mode, as well as providing practice. The Plutonium PAK was used to update the original Duke Nukem 3D to version 1.4,