Garfield: A Week of Garfield, also known as Garfield no Isshukan: A Week of Garfield, is a NES title based on the famous Garfield comic strip. The plot of the game is that Garfield must find Odie, the dog, at the end of the week. In the game, Garfield walks through areas and defeats/avoids enemies. Enemies can be mice, spiders, birds, and more. Your basic attack is a low kick, but you can get several power-ups that have limited ammo.

The game includes many power-ups: a bomb that makes a small fragmented explosion, a bone that is thrown straight forward, and three projectiles all shot at once.