Infamous Second Son is an open-world action-adventure video game. It is a sequel to InFamous 2, yet is not considered a direct sequel, since there are few references to the previous games in the series (except in the "Cole's Legacy" DLC pack).

The game maintains a morality system from the other games, although slightly modified. The player can progress morality ranks in either direction. (to True Hero or to Infamous) This acts in a similar fashion to XP, as it grants the player new unlockable powers that can be purchased using Blast Shards collected throughout the map.

There are four central sources of energy within the game, Smoke (which is unlocked by default), Neon, Video (which both unlock after the player reaches certain parts in the story) and Concrete (which is unlocked once the player completes the game).