Daniel Dollis

Daniel Dollis is a veteran detective with 20 years of experience and a long time colleague of Aya Brea. He is 42 years old and operates in the 17th Precinct of the NYPD. He has a very one-minded nature towards his profession, making him sometimes gruff and disclosed to spending time with his family. It is because of this, that his wife, Lorraine divorces him nearly a year before the events of the game, leaving him with the custody of their son Ben Dollis.

During the events of Parasite Eve, Daniel serves as a supporting role for the Aya, giving her encouraging words of experience while he attempts to function with the terms of his divorce and the eventual death of his ex-wife. Prior to Aya's confrontation of the Ultimate Being, he nearly sacrifices himself in order to deliver special mitochondria]-laced bullets to assist her in the battle. He also finally reconsiders the effects of his neglect of his family in place of his profession and is shown spending time with his son. In the events of the second game, he is presumed to be still working at the NYPD police district. Though he doesn't make an actual appearance, he's briefly mentioned by Aya as being a terrible cook, and is compared with Gary Douglas; Aya considered both men were "stubborn, but with a heart of gold".

Hans Klamp

A 37-year-old scientist that achieved a master's degree in scientific studies and resides at the American Museum of Natural History Laboratory in New York. Sometime during his studies he became obsessed with the study of Mitochondria and its ATP energy, though it is not clear when his motivation changed from studying mitochondria to actively helping Eve.

He is unfriendly and unhelpful when questioned by Aya, and his behavior progresses from merely asocial to actively hostile throughout the course of the game. It is revealed that he was involved in a project to create the modified sperm, free of mitochondria, which was necessary for Eve to birth the Ultimate Being, though it is unclear if this was directly related to Eve's plans or not. Ultimately he combusts into flames after asking Eve to 'take him', in an attempt to kill Aya and her companions.

Kyle Madigan

A 29 year old man born in Texas who claims to be a P.I from Los Angeles and is initially shown as a man with mysterious motives, he is originally found by Aya in Dryfield hiding from the NMCs; however he later forms a team with her to fight the Neo-Mitochondrial Creatures produced by the Shadow government Neo Ark. Towards the end of the game is revealed that Kyle is in fact a U.S Government Special Agent who works directly with the President of the U.S; he played both sides (Neo Ark's and Aya's) to get information and act accordingly. He loses his leg from the concussion blast caused by the orbiting SDI Hypervelocity Railgun directed at the Pupa ANMC. After the events of Dryfield, he disappears, but meets later with Aya, and the new Eve, in New York City. He will reprise his role in The 3rd Birthday, seemingly betraying Aya and having some connection to the new cataclysm in New York.

Rupert Broderick

In Parasite Eve II, Aya departed the NYPD police out of respect for her comrades due to the awakening of her mitochondrial powers and joined the FBI's "MIST" (Mitochondrion Investigation and Suppression Team). Somewhat replacing Daniel Dollis as the supporting character, Rupert is Aya's new partner and provides back-up, saving her from a surprise attack from a ANMC stranger in the beginning of the game. According to his back-story, he fights along with MIST because of an NMC attack on his family, slaughtering his wife and child.

Eric Baldwin

Eric Baldwin is the commanding supervisor of the MIST organization. Baldwin is fifty years old and has a strict and straightforward nature, commanding the MIST team with efficiency. His subordinates nickname him "Hal", though he apparently doesn't know it. It is later revealed in the game that he is actually working in part for the Neo Ark government, which is later discovered by Aya and her colleagues. It is presumed Hal was later given to the authorities

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