- Signals
- Signpost (NWN)
- Sigurd
- Sigurd's Cradle
- Sikh/Freeciv
- Sikkimese/Freeciv
- Sil
- Sila
- Silean Nebula
- Silence (NWN)
- Silencer
- SilentHeroes
- Silent Debuggers
- Silent Hill
- Silent Hill: Book of Memories
- Silent Hill: Downpour
- Silent Hill: Downpour/Soundtrack
- Silent Hill: Homecoming
- Silent Hill: Origins
- Silent Hill: The Arcade
- Silent Hill (film)
- Silent Hill (series)
- Silent Hill 2
- Silent Hill 2 (film)
- Silent Hill 3
- Silent Hill 4: The Room
- Silent Hills
- Silent Hope
- Silent Hunter 4: The U-Boat Missions
- Silent Hunter 4: Wolves of the Pacific
- Silent Hunter II
- Silent Hunter III
- Silent Hunter V: Battle of the Atlantic
- Silent Line: Armored Core
- Silent Night
- Silent Scope
- Silent Scope 2: Dark Silhouette
- Silent Scope Complete
- Silent Scope Light Rifle
- Silent Sector
- Silent Spell (NWN)
- Silent Storm
- Silesian/Freeciv
- Silicon-Galaxy
- Silicon & Synapse
- Silicon Dreams
- Silicon Dreams (series)
- Silicon Knights
- Silk
- Silkroad Online
- Sillysoft Games
- Silpheed
- Silpheed/Codes
- Silt
- Silt/Codex
- Silva
- Silver
- SilverBirch Studios
- Silver (1999)
- Silver (The Last Oricru)
- Silver Armlet/Final Fantasy VII
- Silver Barrette/Final Fantasy VII
- Silver Chains
- Silver Chalice of Moonbow (NWN)
- Silver Chaos
- Silver Charm (NWN)
- Silver Glasses/Final Fantasy VII
- Silver Knights
- Silver M-phone/Final Fantasy VII
- Silver Mario - Metal Keychain
- Silver Necklace (NWN)
- Silver Nornir
- Silver Rifle/Final Fantasy VII
- Silver Ring (KH II)
- Silver Ring (NWN)
- Silver Ring ♯2 (NWN)
- Silver Star
- Silver Strike Bowling
- Silver Style Entertainment
- Silver the Hedgehog
- Silverback II
- Silverfall
- Silverfall (series)
- SimAnimals
- SimAnt: The Electronic Ant Colony
- SimAnt: The Electronic Ant Colony/Cheats
- SimCasino
- SimCasino/Codex
- SimCity
- SimCity/Credits
- SimCity/Walkthrough
- SimCity (series)
- SimCity 2000
- SimCity 2000/Codes
- SimCity 3000
- SimCity 3000/Codes
- SimCity 4
- SimCity 4/Cheats
- SimCity 4: Deluxe Edition
- SimCity 4: Rush Hour
- SimCity 4: Rush Hour/Cheats
- SimCity DS
- SimCity DS/Covers
- SimCity Societies
- SimCity Societies: Destinations
- SimCity series
- SimCopter: Fly Missions in the Metropolis
- SimCopter: Fly Missions in the Metropolis/Cheats
- SimEarth: The Living Planet
- SimFarm: SimCity's Country Cousin
- SimGolf
- SimIsle: Missions in the Rainforest
- SimLife: The Genetic Playground
- SimMars Beta 2 Mod (SimCity 4)
- SimPark
- SimPocalypse
- SimPort
- SimRail 2021 - The Railway Simulator
- SimSafari
- SimSig
- SimTower: The Vertical Empire
- SimTower: The Vertical Empire/Cheats
- SimTown: The Town You Build Yourself!
- SimTunes
- Sim Theme Park
- Simcountry
- Simcountry/Walkthrough
- Simis
- Simming Encyclopedia
- Simon & Schuster Interactive
- Simon (Lil Gator Game)
- Simon Ashford (Terra Nova: Strike Force Centauri)
- Simon Belmont
- Simon Forman (Astrologaster)
- Simon Krasinski
- Simon Riley
- Simon the Sorcerer
- Simon the Sorcerer's Pinball
- Simon the Sorcerer's Puzzle Pack
- Simon the Sorcerer 3D
- Simon the Sorcerer 4: Chaos Happens
- Simon the Sorcerer 5
- Simple Bedding
- Simple DirectMedia Layer
- Simple Recycling
- Simple Sandbox 2
- Simple Sandbox 2/Codex
- Simple Sandbox 2 Maps
- Simple Sandbox 2 Updates
- Simple series
- Simplz: Zoo
- SimsVille
- Simson Tuningwerkstatt 3D
- Simtex
- Simulation Pro Yakyuu
- Simulation RPG Tsukūru
- Simulation racing video games
- Simulation video games
- Simultaneously-executed video games
- Simutrans
- Simutrans experimental
- Sin (BROK the InvestiGator)
- Sin Inc
- Sin and Punishment: Successor of the Earth
- Sinclair ZX81
- Sinclair ZX Spectrum
- Sindel
- Sindibad: Chitei No Dai Makyu
- Sineus
- Sing/Generation I
- Singaporean/Freeciv
- Singing video games
- Single-board computer
- Single-player
- Single-player video game
- SingleTrac
- Single Player Commands
- Single Race (Hotshot Racing)
- Singleplayer Mode (Fear Therapy)
- Singleplayer mode (Cyberfrags '69)
- Singleplayer modes in DRIFT21
- Singles: Flirt Up Your Life
- Singles 2: Triple Trouble
- Singularity
- Singularity Drive
- Sinhalese/Freeciv
- Sinistar
- Sinistar Unleashed
- Sinister Halloween
- Sinister Night
- Sinistron
- Sinking Island
- Sinmara
- Sinners (Hell Architect)
- Sinnoh
- Sinobu Amou
- Sins of a Dark Age
- Sins of a Solar Empire
- Sint Eustatius
- Sint Eustatius in video gaming
- Sint Maarten
- Sint Maarten in video gaming
- Sioux/Freeciv
- Sir-Tech
- Sir Daniel Fortesque
- Sir Gawain (Märchen Forest)
- Sir Hammerlock
- Sir Kibble
- Sir Lancelot
- Sir Swoop
- Sir Whoopass™: Immortal
- Siren's Call
- Siren Head: The Horror Experience
- Siril the Baker
- Sirius Software
- Siroi Danmakukun
- Sirou
- Sirta Foundation
- Sirta Foundation License
- Sister Clara (The Town of Light)
- Sister Psyche
- Sisters of EVE Charity Statue
- Six Days in Fallujah
- Sixaxis Controller
- Sixth generation of video game hardware
- Sixtieth Kilometer
- Sixtieth Kilometer/Codex
- Sixty-Nine
- Size Matters
- Sizeable
- Sizeable/Codex
- Sizeable turtles
- Ska Studios
- Skald: Against the Black Priory
- Skarlet
- Skarmory
- Skate.
- SkateBIRD
- SkateBIRD/Codex
- Skate 2
- Skate 3
- Skate Boardin'
- Skate City
- Skateboard Park Tycoon
- Skating Fox
- Skeet Shoot
- Skelesnail
- Skeletal animation
- Skeleton
- Skeleton's Knuckle (NWN)
- Skeleton (Black Tiger)
- Skeleton (Crystal Castles)
- Skeleton (Ninja-Kid)
- Skeleton (SonSon II)
- Skeleton Crew
- Skeleton Murderer
- Skeleton Neck
- Skelly Selest
- Skelly Selest/Codex
- Skepsis
- Sketchy (Doodle Date)
- SkiFree
- Ski Champ
- Ski Park Manager
- Ski Resort Extreme
- Ski Resort Tycoon
- Ski Resort Tycoon II
- Ski and Shoot
- Skid Cities
- Skies of Arcadia
- Skies of Arcadia/Credits
- Skiing
- Skill
- Skill (Memory Box)
- Skill Affinity (Concentration) (NWN)
- Skill Affinity (Listen) (NWN)
- Skill Affinity (Lore)/Neverwinter Nights
- Skill Affinity (Move Silently) (NWN)
- Skill Affinity (Search) (NWN)
- Skill Affinity (Spot) (NWN)
- Skill Focus (Appraise) (NWN)
- Skill Focus (Concentration) (NWN)
- Skill Focus (Craft Armor) (NWN)
- Skill Focus (Craft Trap) (NWN)
- Skill Focus (Craft Weapon) (NWN)
- Skill Focus (Discipline) (NWN)
- Skill Focus (Heal) (NWN)
- Skill Focus (Hide) (NWN)
- Skill Focus (Intimidate) (NWN)
- Skill Focus (Listen) (NWN)
- Skill Focus (Lore) (NWN)
- Skill Focus (Move Silently) (NWN)
- Skill Focus (Open Lock) (NWN)
- Skill Focus (Parry) (NWN)
- Skill Focus (Persuade) (NWN)
- Skill Focus (Search) (NWN)
- Skill Focus (Spellcraft) (NWN)
- Skill Focus (Spot) (NWN)
- Skill Focus (Taunt) (NWN)
- Skill Ring (KH II)
- Skill With Prize
- Skill tree
- Skillful Ring (KH II)
- Skills & Items (Broken Universe - Tower Defense)
- Skills (DARK)
- Skills (Hell Pie)
- Skinwalker
- Skinwalker Hunt
- Skinwalker Hunt/Codex
- Skip Ltd.
- Skiploom
- Skipper
- Skips (BETON BRUTAL)
- Skitso Productions
- Skorp
- Skull
- SkullWiriLiami
- Skull (Marchen Maze)
- Skull Bash/Generation I
- Skull Coin
- Skull Coin (Black Tiger)
- Skull Fang Kuhga Gaiden
- Skull Kid
- Skull Wall
- Skull Warrior's Head (NWN)
- Skullpin
- Skullstone
- Skully
- Skweek
- SkyBox Labs
- SkyIsland
- Sky Attack/Generation I
- Sky Diver
- Sky Fleet
- Sky Fox
- Sky Jinks
- Sky Kid
- Sky Kid Deluxe
- Sky Link: Freefire
- Sky Noon
- Sky Noon/Codex
- Sky Racket
- Sky Skipper
- Skyborg: Into the Vortex
- Skydrift Infinity
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