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Leon S. Kennedy
A character first featured in Resident Evil 2, Leon S. Kennedy is now an agent working for the American government who is tasked with protecting the President's family. With his government training Leon has mastery over a wide range of weapons as well as being skilled in self-defence.
The United States President's daughter, whom Leon was ordered to rescue when she was kidnapped. She was captured under the orders of Osmund Saddler who plans to primarily use her for his plans for world domination.
A character that was first featured in Resident Evil 2. She seemingly worked for Wesker, but is actually a double agent. Her mission was to receive a sample of Las Plagas for Wesker, but she gave him a fake one instead.
A character featured in many other Resident Evil games. He seems to want to resurrect Umbrella Corporation. He seemingly had superhuman strength and agility, as demonstrated in Resident Evil 5.
A mysterious Spaniard who has gone from working with the Los Illuminados to working against them. Though his intentions are unknown, he is surely friend, not foe.
Leon's contact with his agency, and the only link between Leon and the civilized world. She calls Leon S. Kennedy frequently but the line was jacked by Osmund Saddler and Ramon Salazar.
The leader of the village where the game begins. After Leon defeats him, you use his false eye to open a door out of the village. He serves as the quaranty antagonist of the game.
He used to work with Leon but later turned against him and became a henchman for Osmund Saddler. He wields a knife and later in the game Krauser reveals his Plagas arm but Leon kills him. He serves as the secondary antagonist of the game.
The leader of the main cult in the game the "Los Illuminados" and he is also the final boss. Shortly after you meet up with "Luis Sera" you see a cutscene, where Leon gets an egg implanted into him. After you rescue Ashley, you see Saddler doing the same to her too. In the castle, before the part where you play Ashley, "Luis Sera" appears with "the sample" and then Saddler kills him. He serves as the main antagonist of the game,
A 20 year old Castellan who owns a castle he has two body guards who has been having the Queen Plagas and is in control of the Ganados. He is the eighth Castellan and later in the game he turns into a Master Plagas, but is killed by Leon. He serves as the tertiary antagonist of the game.