The Sega CD version has a password system to continue the game from a set point. The game begins with Doctor Octopus and Electro available in the map. The Lizard and Sandman appear in the map when Dr. Octopus is defeated, and Vulture after defeating Electro. Mysterio appears after Vulture's defeat. After defeating all the six, Hobgoblin appears, followed by Venom and then the Kingpin.

PasswordBosses defeated
HALF2LIFEDr. Octopus and Electro
WALLABYElectro and Vulture
MECHANICDr. Octopus and Sandman
TOTALLY2Dr. Octopus and Lizard
GALLON66Electro, Vulture and Mysterio
MONSTER4Dr. Octopus, Electro and Vulture
COWBOY36Dr. Octopus, Electro and Sandman
STABLE8Dr. Octopus, Electro and Lizard
REACTOR5Dr. Octopus, Sandman and Lizard
FALCON499Dr. Octopus, Electro, Vulture and Mysterio
MARBLETOPDr. Octopus, Electro, Vulture and Sandman
SCHMENGEDr. Octopus, Electro, Vulture and Lizard
PERMANENTDr. Octopus, Electro, Sandman and Lizard
HELPINHANDDr. Octopus, Electro, Vulture, Mysterio and Sandman
SNIGLET7Dr. Octopus, Electro, Vulture, Mysterio and Lizard
NORBLEDr. Octopus, Electro, Vulture, Sandman and Lizard
PUBLIC45Dr. Octopus, Electro, Vulture, Mysterio, Sandman and Lizard

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