Zool 2 is the sequel to Zool. It was released on the Atari jaguar. It has improved graphics and an attempt at a plot. It received generally high review scores, but did not make an impact the way its predecessor had.

The nemesis in the game was named Mental Block, a play on the British English use of the word "mental", a colloquial synonym for crazy.

Zool 2 added the option to play as Zool's female counterpart, Zooz. The two characters played similarly, although there were some subtle differences in their abilities. Most notably, Zool could destroy parts of the scenery that Zooz couldn't, and vice versa, resulting in a slightly different route through the level.