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Zool 2 is the sequel to Zool. It was released on the Amiga, Amiga CD32, Jaguar and for DOS. It received generally high review scores, but did not make an impact the way its predecessor had.
The nemesis in the game is named Mental Block, a play on the British English use of the word "mental", a colloquial synonym for "crazy".
Zool 2 added the option to play as Zool's female counterpart, Zooz. The two characters played similarly, although there were some subtle differences in their abilities. Most notably, Zool could destroy parts of the scenery that Zooz couldn't, and vice-versa, resulting in a slightly different route through the level similar to the way that Sonic & Knuckles would implement this feature.